The dynamics of cytolytic syndrome parameters in the period of late manifestations of cranioskeletal trauma in case of concomitant chronic hepatitits and the effectiveness of armadine correction

Relevance. Cranioskeletal trauma has the most severe lesions and is accompanied by significant mortality. The impact of comorbidities caused cardiovascular system, in particular diffuse internal organs are not fully investigated under this condition. A common mechanism pathogenesis these pathological processes development cytolytic syndrome.
 Goal study: to determine dynamics markers cytolysis period late manifestations cranioskeletal conditions concomitant chronic hepatitis evaluate effectiveness armadine correction.
 Materials methods. trauma, hepatitis, its combinations were modelled separate groups nonlinear white male rats. Armadine at a dose 20 mg/kg intraperitoneally was used correct group with combined lesions. activity alanine aspartate aminotransferases determined serum experimental animals on 14, 21, 28 35 days after injury.
 Results discussion. application traumatic disease increased cytolysis. ampartate aminotransferase injured 14 post-traumatic continues increase up 21 subsequent decrease. Moreover, only reaches level control, while remain significantly higher. use armadin from 21st day experiment causes decrease changes studied parameters compared without Conclusions. background greater change than liver damage. statistically intensity detected disorders, starting experiment.